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Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4, Pages 433-444 doi: 10.1007/s11705-014-1454-6

Abstract: The aggregation of amyloid -protein (A ) is tightly linked to the pathogenesis of Alzheimer’s diseasePrevious studies have found that three peptide inhibitors (i.e., KLVFF, VVIA, and LPFFD) can inhibit

Keywords： Alzheimer’s disease amyloid βi>-protein peptide inhibitors protein-protein interaction molecular

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of a heptapeptide eliminates its cytotoxicity and significantly increases its inhibition effect on amyloid

Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 2, Pages 283-295 doi: 10.1007/s11705-017-1687-2

Abstract: Amyloid- (A ) protein aggregation is the main hallmark of Alzheimer’s disease (AD).indicate that the peptide cyclization is a promising approach to enhance the performance of peptide-based amyloid

Keywords： Alzheimer’s disease amyloid βi>-protein cyclic peptide inhibition protein aggregation

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Construction of a CaHPO4-PGUS1 hybrid nanoflower through protein-inorganic self-assembly, and its application

Tian Jiang, Yuhui Hou, Tengjiang Zhang, Xudong Feng, Chun Li

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 3, Pages 554-562 doi: 10.1007/s11705-019-1834-z

Abstract: method was established to prepare a CaHPO -PGUS1 hybrid nanoflower for enzyme immobilization, based on protein-inorganic

Keywords： βi>-glucuronidase enzyme-inorganic hybrid nanoflower biotransformation glycyrrhizin glycyrrtinicacid 3-Oi>-mono-βi>-D-glucuronide

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Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 378-388 doi: 10.1007/s11684-021-0840-y

Abstract: Macrolide and corticosteroid resistance has been reported in patients with Mycoplasma pneumoniaei> (MP) pneumonia (MPP).The Fc fragment of the IgG-binding protein (FCGBP) was identified as the most promising indicator of

Keywords： severe Mycoplasma pneumoniaei> pneumonia children proteomics Fc fragment of the IgG-binding protein

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Production of rhamnolipids-producing enzymes of

Kata Kiss,Wei Ting Ng,Qingxin Li

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1, Pages 133-138 doi: 10.1007/s11705-017-1637-z

Abstract: Rhamnolipids are a class of biosurfactants that have a great potential to be used in industries. Five proteins/enzymes, namely RhlA, RhlB, RhlC, RhlG and RhlI, are critical for the production of rhamnolipids in . Four of the 5 proteins except RhlC were successfully over-expressed in and three of them (RhlA, RhlB and RhlI) were purified and obtained in milligram quantities. The purified proteins were shown to be folded in solution. Homology models were built for RhlA, RhlB and RhlI. These results lay a basis for further structural and functional characterization of these proteins to favor the construction of super strains for rhamnolipids production.

Keywords： rhamnolipids Pseudomonasi> RhlA RhlB RhlI protein folding

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Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2, Pages 232-237 doi: 10.1007/s11705-012-1286-1

Abstract: groups of animals were examined respectively for inoculation of inhibitor of p38 MAPK (mitogen activated protein

Keywords： connective tissue mitogen activated protein kinase (MAPK) p38 JNK

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immune mapped protein 1 (NcIMP1) is a novel vaccine candidate against neosporosis

Xia CUI,Daoyu YANG,Tao LEI,Hui WANG,Pan HAO,Qun LIU

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1, Pages 66-72 doi: 10.15302/J-FASE-2015047

Abstract: The immune mapped protein 1 (NcIMP1) was identified as a membrane protein, and a previous study indicatedThe experiment was terminated 30 days p.i., and the cerebral parasite burden in each mouse was assessed

Keywords： Neospora caninumi> immune mapped protein 1 (IMP1) vaccine candidate BALB/c mice

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Fabrication of high-capacity cation-exchangers for protein adsorption: Comparison of grafting-from and

Ming Zhao, Run Liu, Jian Luo, Yan Sun, Qinghong Shi

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 1, Pages 120-132 doi: 10.1007/s11705-018-1730-y

Abstract: Protein adsorption on these two cation exchangers have been also investigated.Moreover, the results from protein uptake experiments indicate that the facilitated transport of adsorbedOur research provides a clear clue for the development of high-performance protein chromatography.

Keywords： polymer-grafted ionic exchanger grafting technique protein adsorption atom transfer radical polymerization γi>-globulin

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Characterization of polyclonal antibodies against nonstructural protein 9 from the porcine reproductive

Mengmeng ZHAO,Juanjuan QIAN,Jiexiong XIE,Tiantian CUI,Songling FENG,Guoqiang WANG,Ruining WANG,Guihong ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2, Pages 153-160 doi: 10.15302/J-FASE-2016097

Abstract: The nonstructural protein 9 gene, , encoding the RNA-dependent RNA polymerase, is generally regarded

Keywords： PRRSV Nspi>9 expression antibody neutralize

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Transgenic technologies in cassava for nutritional improvement and viral disease resistance: a key strategy for food security in Africa

Maliwan NACONSIE,Peng ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 4, Pages 285-294 doi: 10.15302/J-FASE-2016119

Abstract: This report presents several successful case studies on engineering protein content by overexpression

Keywords： Manihot esculentai> protein enhancement RNA interference transgenesis virus resistance

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Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Article

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Engineering 2021, Volume 7, Issue 10, Pages 1441-1451 doi: 10.1016/j.eng.2020.07.014

Abstract: mass spectrometry (MS)-based study, we reveal that out of 21 possible glycosites in the HCoV-19 spike protein(S protein), 20 are completely occupied by N-glycans, predominantly of the oligomannose typeAll seven glycosylation sites in human angiotensin I converting enzyme 2 (hACE2) were found to be completelyHowever, glycosylation did not directly contribute to the binding affinity between HCoV-19 S proteinRefined structural models of HCoV-19 S protein and hACE2 were built by adding N-glycan and PTMs

Keywords： Ni>-glycosylation COVID-19 Spike protein hACE2 Structure

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Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 4, Pages 448-455 doi: 10.1007/s11709-014-0262-x

Abstract: Rock mass classification system is very suitable for various engineering design and stability analysis. classification method is confirmed by Japan Highway Public Corporation that this method can figure out either strength or deformability of rock mass, further appropriating the amount of rock bolts, thickness of shotcrete, and size of pitch of steel ribs just after the blasting procedure. Based on these advantages of method, in this study, according to data of five deep and long tunnels in Iran, two equations for estimating the value of method from and classification systems were developed. These equations as a new method were able to optimize the support system for and classification systems. From classification and its application in these case studies, it is pointed out that the method for the design of support systems in underground working is more reliable than the and classification systems.

Keywords： JHi> classification Qi> and RMRi> classification new method

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The Potential Role of Powdery Mildew-Resistance Gene Pm40i> in Chinese Wheat-Breeding Programs inthe Post-Pm21i> Era Perspective

Shengwen Tang,Yuting Hu,Shengfu Zhong,Peigao Luo

Engineering 2018, Volume 4, Issue 4, Pages 500-506 doi: 10.1016/j.eng.2018.06.004

Abstract:

Powdery mildew, which is caused by Blumeria graminis f. sp. tritici (Bgt), is an important leaf disease that affects wheat yield. Powdery mildew-resistance (Pm) gene Pm21 was first transferred into wheat in the 1980s, by translocating the Heuchera villosa chromosome arm 6VS to the wheat chromosome arm 6AL (6VS·6AL). Recently, new Bgt isolates that are virulent to Pm21 have been identified in some wheat fields, indicating that wheat breeders should be aware of the risk of deploying Pm21, although pathological details regarding these virulent isolates still remain to be discovered. Pm40 was identified and mapped on the wheat chromosome arm 7BS from several wheat lines developed from the progenies of a wild cross between wheat and Thinopyrum intermedium. Pm40 offers a broad spectrum of resistance to Bgt, which suggests that it is likely to provide potentially durable resistance. Cytological methods did not detect any large alien chromosomal segment in the wheat lines carrying Pm40. Lines with Pm40 and promising agronomical traits have been released by several wheat-breeding programs in the past several years. Therefore, we believe that Pm40 will play a role in powdery mildew-resistance wheat breeding after Pm21 resistance is overcome by Bgt isolates. In addition, both Pm21 and Pm40 were derived from alien species, suggesting that the resistance genes derived from alien species are potentially more durable or effective than those identified from wheat.

Keywords： Wheat Powdery mildew Pm21i> Pm40i> Alien species Native resistance

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NiFeRuO_xi> nanosheets on Ni foam as an electrocatalyst for efficient

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 11, Pages 1698-1706 doi: 10.1007/s11705-023-2334-8

Abstract: The electrocatalyst NiFeRuO_xi>/NF, comprised of NiFeRuO_xi> nanosheetsNiFeRuO_xi>/NF displays high electrocatalytic activity and stability for overall alkalineA solar-driven system containing such a bifunctional NiFeRuO_xi>/NF has an almost 100%The NiFeRuO_xi> coating around Ni foam is an anti-corrosion layer and also a critical

Keywords： NiFeRuO_xi> nanosheets Ni foam electrocatalysis overall seawater splitting solar-driven

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Biosynthesis and Immunological Evaluation of a Dual-Antigen Nanoconjugate Vaccine against Brucellamelitensisi> Article

Jing Huang, Yufei Wang, Kangfeng Wang, Shulei Li, Peng Sun, Yan Guo, Jiankai Liu, Ruifu Yang, Ming Zeng, Chao Pan, Hengliang Wang, Li Zhu

Engineering 2023, Volume 29, Issue 10, Pages 95-109 doi: 10.1016/j.eng.2023.04.007

Abstract: In this study, we developed a dual-antigen nanoconjugate vaccine containing both polysaccharide and proteinFirst, the antigenic polysaccharide was covalently coupled to the outer membrane protein Omp19 usingprotein glycan coupling technology, and then it was successfully loaded on a nano-carrier through theknowledge, this is the first Brucella
vaccine bearing diverse antigens, including a protein

Keywords： Protein glycan coupling technology (PGCT) Dual-antigen Nanoconjugate vaccine Brucella melitensisi>

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Title Author Date Type Operation

Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Journal Article

of a heptapeptide eliminates its cytotoxicity and significantly increases its inhibition effect on amyloid

Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun

Journal Article

Construction of a CaHPO4-PGUS1 hybrid nanoflower through protein-inorganic self-assembly, and its application

Tian Jiang, Yuhui Hou, Tengjiang Zhang, Xudong Feng, Chun Li

Journal Article

Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Journal Article

Production of rhamnolipids-producing enzymes of

Kata Kiss,Wei Ting Ng,Qingxin Li

Journal Article

Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Journal Article

immune mapped protein 1 (NcIMP1) is a novel vaccine candidate against neosporosis

Xia CUI,Daoyu YANG,Tao LEI,Hui WANG,Pan HAO,Qun LIU

Journal Article

Fabrication of high-capacity cation-exchangers for protein adsorption: Comparison of grafting-from and

Ming Zhao, Run Liu, Jian Luo, Yan Sun, Qinghong Shi

Journal Article

Characterization of polyclonal antibodies against nonstructural protein 9 from the porcine reproductive

Mengmeng ZHAO,Juanjuan QIAN,Jiexiong XIE,Tiantian CUI,Songling FENG,Guoqiang WANG,Ruining WANG,Guihong ZHANG

Journal Article

Transgenic technologies in cassava for nutritional improvement and viral disease resistance: a key strategy for food security in Africa

Maliwan NACONSIE,Peng ZHANG

Journal Article

Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Journal Article

Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

Journal Article

The Potential Role of Powdery Mildew-Resistance Gene Pm40i> in Chinese Wheat-Breeding Programs inthe Post-Pm21i> Era

Shengwen Tang,Yuting Hu,Shengfu Zhong,Peigao Luo

Journal Article

NiFeRuO_xi> nanosheets on Ni foam as an electrocatalyst for efficient

Journal Article

Biosynthesis and Immunological Evaluation of a Dual-Antigen Nanoconjugate Vaccine against Brucellamelitensisi>

Jing Huang, Yufei Wang, Kangfeng Wang, Shulei Li, Peng Sun, Yan Guo, Jiankai Liu, Ruifu Yang, Ming Zeng, Chao Pan, Hengliang Wang, Li Zhu

Journal Article

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